Timeline of Past News


  • September 2022: Presenting our data on the obscurin/Obsl1 double knockout as new diastolic dysfunction heart failure model in comparison to the 'two-hit' model of heart failure with preserved ejection fraction at the 2022 'Metabolism in Action' Conference.
  • Metabolism in Action Conference 2022
  • August 2022: We have a new picture of the lab with collaborators and friends.
  • 2022 lab picture
  • July 2022: Our Obscn & Obsl1 gene targeted mice 🐭 are now available at Jackson Laboratories. A great tool for skeletal muscle and cardiac research. Follow the links for more info on the Obscurin and Obsl1 lines.
    We are also working on a new manuscript detailing Obscn/Obsl1 function for hearts
    #preprint #ComingSoon.
  • June 2022: Our new collaborative manuscript on adipose tissue inflammation and cardiometabolic disease with the Borgeson lab @Unversity of Gothenburg is out in iScience.
  • iScience 2022 manuscript
  • June 2022: We presented data at the ISHR meeting in Berlin, Germany. Madison Clark won a poster award for her work.
  • Madison ISHR
  • May 2022: Madison Clark successfully defended her collaborative Masters Thesis with the group of Assoc. Prof. Borgeson at the University of Gothenburg. Congratulations!
  • Madison Thesis Defence
  • January 2022: We contributed to a collaborative manuscript from the group of Prof. Sorrentino on obscurin functions in skeletal muscles.
  • Obscurin KO muscle MS 2022


  • September 2021: Check out our new review article on the titin N2B and N2A regions as biomechanical and metabolic signaling hubs in cross-striated muscles published in Biophysical Reviews.
  • The titin I-band as biomechanical and signaling hub
  • May 2021: Something entirely different from the usual projects in the lab: We looked at challenges to the education of PhD students at universities in Sweden due to COVID-19. The accepted manuscript is now available at BMC Medical Education.
  • Impact of covid on PhD education in Sweden
  • April 2021: We collaborated with the Sheikh Lab at UC San Diego to uncover cardiac functions of the Cop9 Signalosome unit Csn6. The manuscript was recently published at the Journal of Clinical Investigations (JCI).
  • Cardiac Csn6 knockout manuscript
  • April 2021: We have a new collaborative manuscript describing the structure of titin Ig81-83 availabe at the Journal of General Physiology.
  • titin Ig81-83 structure
  • March 2021: Discover our new manuscript that explores obscurin and SPEG kinase biology. The open access article is published here. Another paper with a fantastic team of collaborators- Dr. Fleming at the University of Konstanz and the Borgeson lab at the University of Gothenburg.
  • Exploring obscurin and SPEG kinase biology
  • February 2021: New manuscript on Ankrd1/Carp1 binding to titin N2a and filamentous actin; published in the Journal of Molecular Biology. Great collaborative effort with the labs of Olga Mayans, Wolfgang Linke, Michael Kovermann, Belinda Bullard, Ju Chen and Emma Borgeson.
  • Ankrd1/titin/F-actin binding interface


  • October 2020: Read our new review on the role of cullin-RING ligases for the development and function of cross-striated muscles. The open access article is published here.
  • Cullin-Review article
  • September 2020: We presented data on the role of obscurin proteins for cardiac health at a symposium in Bern, Switzerland.
  • September 2020: We attended the virtual Keystone Symposium on Proteomics in Cell Biology and Disease. We featured our work on cardiac phospho-proteomics and its role in the development of dilated cardiomyopathy.
  • July 2020: Our work combatting Dilated Cardiomyopathy is featured in the Saltman Quarterly.
  • Saltman Article
  • March-June 2020: Keeping the lab going in times of social distancing.
  • Zoom Meeting
  • January 2020: We are grateful to have received major funding from the Muscular Dystrophy Association to organize the 2020 AMC Meeting.
    Due to the COVID-19 outbreak, we were unfortunately forced to cancel the meeting.
  • MDA