Research Focus

Our research interest is to investigate muscle development, signaling and maintenance, by studying the biological role of sarcomeric and muscle associated proteins. Specifically, we are interested in the molecular origins and pathways associated with the development and progression of human cardiac and skeletal myopathies.

Select an option below to learn more about the basics of cross-striated muscles, or the projects in the lab investigating muscle formation, maintenance, signaling and disease.

the basics

the sarcomere
sarcomere associated proteins
muscle signaling and turnover
muscle diseases - coming soon

the projects

proteins & mechanisms

diseases

cardiomyopathies

dilated cardiomyopathy (DCM)
hypertrophic cardiomyopathy (HCM)
diastolic dysfunction &
heart-failure with preserved ejection fraction (HFpEF)
hypoplastic left heart syndrome (HLHS)

skeletal muscle diseases

limb-girdle muscular dystrophy (LGMD)
nemaline myopathy (NM)

Support our work

get involved and support research on our projects

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