Publications

Here is a list of our most recent publications.
The COMPLETE LIST of publications can be found at Pubmed, or ORCID: 0000-0001-9361-6602.

Metabolic Flexibility of the Heart: The Role of Fatty Acid Metabolism in Health, Heart Failure, and Cardiometabolic Diseases Actis Dato V, Lange S, Cho Y. Int. J. Mol. Sci. 2024 Jan 19. doi:10.3390/ijms25021211. Combined loss of obscurin and obscurin-like 1 in murine hearts results in diastolic dysfunction, altered metabolism and deregulated mitophagy: Profile on PlumX Students at a crossroad: A cross-sectional survey gauging the impact of COVID-19 on medical and biomedical graduates in the United States and Sweden Lange S, Soták M, Hagberg CE, Bagunu G, Vigmo S, Börgeson E. Biochem Mol Biol Educ. 2023 Jun 24. doi:10.1002/bmb.21761. Combined loss of obscurin and obscurin-like 1 in murine hearts results in diastolic dysfunction, altered metabolism and deregulated mitophagy: Profile on PlumX PREPRINT: Combined loss of obscurin and obscurin-like 1 in murine hearts results in diastolic dysfunction, altered metabolism and deregulated mitophagy Fujita K, Desmond P, Marrocco V, Blondelle J, Sotak M, Rajan M, Esteve E, Chan Y, Clark M, Gu Y, Dalton N, Ghassemian M, Do A, Klos M, Borgeson E, Peterson K, Shekh F, Lange S. bioRxiv. 2022. doi:10.1101/2022.08.24.505098. Combined loss of obscurin and obscurin-like 1 in murine hearts results in diastolic dysfunction, altered metabolism and deregulated mitophagy: Profile on PlumX Lipoxins reduce obesity-induced adipose tissue inflammation in 3D-cultured human adipocytes and explant cultures. Soták M, Rajan M, Clark M, Harms M, Rani A, Kraft J, Tandio D, Shen T, Borkowski K, Fiehn O, Newman O, Quiding-Järbrink M, Biörserud C, Apelgren P, Staalesen T, Hagberg C, Boucher J, Wallenius V, Lange S, Börgeson E. iScience. 25, 104602, July 15, 2022. doi:10.1016/j.isci.2022.104602. Lipoxins reduce obesity-induced adipose tissue inflammation in 3D-cultured human adipocytes and explant cultures: Profile on PlumX Impaired Intracellular Ca2+ Dynamics, M-Band and Sarcomere Fragility in Skeletal Muscles of Obscurin KO Mice. Pierantozzi E, Szentesi P, Paolini C, Dienes B, Fodor J, Oláh T, Colombini B, Rassier DE, Rubino EM, Lange S, Rossi D, Csernoch L, Bagni MA, Reggiani C, Sorrentino V. Int. J. Mol. Sci. 2022, 23, 1319. doi:10.3390/ijms23031319. Impaired Intracellular Ca2+ Dynamics, M-Band and Sarcomere Fragility in Skeletal Muscles of Obscurin KO Mice: Profile on PlumX The titin N2B and N2A regions: biomechanical and metabolic signaling hubs in cross-striated muscles. van der Pijl R, Domenighetti A, Sheikh F, Ehler E, Ottenheijm C, Lange S. Biophys Rev. (2021). doi:10.1007/s12551-021-00836-3. The titin N2B and N2A regions: biomechanical and metabolic signaling hubs in cross-striated muscles: Profile on PlumX Challenges in PhD education due to COVID-19 - disrupted supervision or business as usual: a cross-sectional survey of Swedish biomedical sciences graduate students. Börgeson E, Sotak M, Kraft J, Bagunu G, Biörserud C, Lange S. BMC Med Educ 21, 294 (2021). doi:10.1186/s12909-021-02727-3. Challenges in PhD education due to COVID-19 - disrupted supervision or business as usual: a cross-sectional survey of Swedish biomedical sciences graduate students: Profile on PlumX Desmosomal COP9 regulates proteome degradation in arrhythmogenic right ventricular dysplasia/cardiomyopathy. Liang Y, Lyon RC, Pellman J, Bradford WH, Lange S, Bogomolovas J, Dalton ND, Gu Y, Bobar M, Lee MH, Iwakuma T, Nigam V, Asimaki A, Scheinman M, Peterson KL, Sheikh F. J Clin Invest. 2021. PMID: 33857019. doi:10.1172/JCI137689. Desmosomal COP9 regulates proteome degradation in arrhythmogenic right ventricular dysplasia/cardiomyopathy: Profile on PlumX The N2A region of titin has a unique structural configuration. Stronczek C, Lange S, Bullard B, Wolniak S, Börgeson E, Mayans O, Fleming JR. J Gen Physiol. 2021. PMID: 33836065. doi:10.1085/jgp.202012766. The N2A region of titin has a unique structural configuration: Profile on PlumX Exploring Obscurin and SPEG Kinase Biology. Fleming JR, Rani A, Kraft J, Zenker S, Börgeson E and Lange S. JCM. 2021 doi:10.3390/jcm10050984. Exploring Obscurin and SPEG Kinase Biology: Profile on PlumX Molecular characterisation of titin N2A and its binding of CARP reveals a titin/actin cross-linking mechanism. Zhou T, Fleming JR, Lange S, Hessel AL, Bogomolovas J, Stronczek C, Grundei D, Ghassemian M, Biju A, Börgeson E, Bullard B, Linke WA, Chen J, Kovermann M, Mayans O. JMB. 2021 doi:10.1016/j.jmb.2021.166901. Molecular characterisation of titin N2A and its binding of CARP reveals a titin/actin cross-linking mechanism: Profile on PlumX The Role of Cullin-RING Ligases in Striated Muscle Development, Function, and Disease. Blondelle J, Biju A, Lange S. Int. J. Mol. Sci. 2020, 21(21), 7936. doi: 10.3390/ijms21217936. The Role of Cullin-RING Ligases in Striated Muscle Development, Function, and Disease: Profile on PlumX Comparative analysis of obesity-related cardiometabolic and renal biomarkers in human plasma and serum. Rohini Rajan M, Sotak M, Barrenäs F, Shen T, Borkowski K, Ashton NJ, Biörserud C, Lindahl TL, Ramström S, Schöll M, Lindahl P, Fiehn O, Newman JW, Perkins R, Wallenius V, Lange S & Börgeson E. Scientific Reports volume 9, Article number: 15385 (2019). doi: 10.1038/s41598-019-51673-0. Comparative analysis of obesity-related cardiometabolic and renal biomarkers in human plasma and serum: Profile on PlumX miR-486 is modulated by stretch and increases ventricular growth. Lange S, Banerjee I, Carrion K, Serrano R, Habich L, Kameny R, Lengenfelder L, Dalton N, Meili R, Börgeson E, Peterson K, Ricci M, Lincoln J, Ghassemian M, Fineman JR, Del Álamo JC, Nigam V. JCI Insight. 2019 Sep 12. doi: 10.1172/jci.insight.125507. miR-486 is modulated by stretch and increases ventricular growth: Profile on PlumX Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism. Blondelle J, Marrocco V, Clark M, Desmond P, Myers S, Nguyen J, Wright M, Bremner S, Pierantozzi E, Ward S, Estève E, Sorrentino V, Ghassemian M, Lange S. Communications Biology. 2019 May 9. doi: 10.1038/s42003-019-0405-7. Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism: Profile on PlumX Cullin-3 dependent deregulation of ACTN1 represents a new pathogenic mechanism in nemaline myopathy. Blondelle J, Tallapaka K, Seto JT, Ghassemian M, Clark M, Laitila JM, Bournazos A, Singer JD, Lange S. JCI Insight. 2019 Apr 16;5. pii: 125665. doi: 10.1172/jci.insight.125665. Cullin-3 dependent deregulation of ACTN1 represents a new pathogenic mechanism in nemaline myopathy: Profile on PlumX The M-band: The underestimated part of the sarcomere. Lange S, Pinotsis N, Agarkova I, Ehler E. Biochim Biophys Acta Mol Cell Res. 2019 Feb 7. doi: 10.1016/j.bbamcr.2019.02.003. The M-band: The underestimated part of the sarcomere: Profile on PlumX PKC and PKN in heart disease. Marrocco V, Bogomolovas J, Ehler E, Dos Remedios CG, Yu J, Gao C, Lange S. J Mol Cell Cardiol. 2019 Feb 8. doi: 10.1016/j.yjmcc.2019.01.029. PKC and PKN in heart disease: Profile on PlumX Mutant Muscle LIM Protein C58G causes cardiomyopathy through protein depletion. Ehsan M, Kelly M, Hooper C, Yavari A, Beglov J, Bellahcene M, Ghataorhe K, Poloni G, Goel A, Kyriakou T, Fleischanderl K, Ehler E, Makeyev E, Lange S, Ashrafian H, Redwood C, Davies B, Watkins H, Gehmlich K. J Mol Cell Cardiol. 2018 Jul 23. doi: 10.1016/j.yjmcc.2018.07.248. Mutant Muscle LIM Protein C58G causes cardiomyopathy through protein depletion: Profile on PlumX Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy. Fang X, Bogomolovas J, Wu T, Zhang W, Liu C, Veevers J, Stroud MJ, Zhang Z, Ma X, Mu Y, Lao DH, Dalton ND, Gu Y, Wang C, Wang M, Liang Y, Lange S, Ouyang K, Peterson KL, Evans SM, Chen J. JCI. 2017 Jul 24. doi: 10.1172/JCI94310. Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy: Profile on PlumX Cullin E3 ligase activity is required for myoblast differentiation. Blondelle J, Shapiro P, Domenighetti AA, Lange S. JMB. 2017 Feb 24. doi: 10.1016/j.jmb.2017.02.012. Cullin E3 ligase activity is required for myoblast differentiation: Profile on PlumX Exercise-induced alterations and loss of sarcomeric M-line organization in the diaphragm muscle of obscurin knockout mice. Randazzo D, Blaauw B, Paolini C, Pierantozzi E, Spinozzi S, Lange S, Chen J, Protasi F, Reggiani C, Sorrentino V. Am J Physiol Cell Physiol. 2016 Oct 26:ajpcell.00098.2016. doi: 10.1152/ajpcell.00098.2016.PMID: 27784675 Exercise-induced alterations and loss of sarcomeric M-line organization in the diaphragm muscle of obscurin knockout mice: Profile on PlumX Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin's I-band: the cardiomyopathy-linked mutation T2580I. Bogomolovas J, Fleming JR, Anderson BR, Williams R, Lange S, Simon B, Khan MM, Rudolf R, Franke B, Bullard B, Rigden DJ, Granzier H, Labeit S, Mayans O. Open Biol. 2016 Sep;6(9). pii: 160114. DOI: 10.1098/rsob.160114 PMID: 27683155 Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin's I-band: the cardiomyopathy-linked mutation T2580I: Profile on PlumX MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy. Lange S, Gehmlich K, Lun AS, Blondelle J, Hooper C, Dalton ND, Alvarez EA, Zhang X, Bang ML, Abassi YA, Dos Remedios CG, Peterson KL, Chen J, Ehler E. Nat Commun. 2016 Jun 29;7:12120. doi: 10.1038/ncomms12120. PMID: 27353086 MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy: Profile on PlumX Cypher and enigma homolog protein are essential for cardiac development and embryonic survival. Mu Y, Jing R, Peter AK, Lange S, Lin L, Zhang J, Ouyang K, Fang X, Veevers J, Zhou X, Evans SM, Cheng H, Chen J. J Am Heart Assoc. 2015 May 5;4(5). PMID:25944877 Cypher and enigma homolog protein are essential for cardiac development and embryonic survival: Profile on PlumX Cathepsins in Heart Disease - Chewing on the Heartache? Blondelle J, Lange S, Greenberg BH, Cowling RT. Am J Physiol Heart Circ Physiol. 2015 Mar 6. PMID:25747750 Cathepsins in Heart Disease - Chewing on the Heartache?: Profile on PlumX Cardiac Cytoarchitecture: How to Maintain a Working Heart-Waste Disposal and Recycling in Cardiomyocytes. Jordan Blondelle & Stephan Lange. Book Chapter in Cardiac Cytoarchitecture. Edited by Elisabeth Ehler. Springer International Publishing Switzerland. 2015. ISBN: 978-3-319-15262-2 (Print) 978-3-319-15263-9 (Online). Online Version Cardiac Cytoarchitecture: How to Maintain a Working Heart-Waste Disposal and Recycling in Cardiomyocytes: Profile on PlumX Cyclic stretch of embryonic cardiomyocytes increases proliferation, growth, and expression while repressing Tgf-beta signaling. Banerjee I, Carrion K, Serrano R, Dyo J, Sasik R, Lund S, Willems E, Aceves S, Meili R, Mercola M, Chen J, Zambon A, Hardiman G, Doherty TA, Lange S, Del Alamo JC, Nigam V. J Mol Cell Cardiol. 2014 Nov 13;79C:133-144. doi: 10.1016/j.yjmcc.2014.11.003. PMID: 25446186 Cyclic stretch of embryonic cardiomyocytes increases proliferation, growth, and expression while repressing Tgf-beta signaling: Profile on PlumX Probing Muscle Ankyrin-Repeat Protein (MARP) Structure and Function. Lun AS, Chen J, Lange S. Anat Rec. 2014 Aug;14. DOI: 10.1002/ar.22968. See at the publisher Probing Muscle Ankyrin-Repeat Protein (MARP) Structure and Function: Profile on PlumX Isolation and culture of neonatal mouse cardiomyocytes. Ehler E, Moore-Morris T, Lange S. J Vis Exp. 2013 Sep 6;(79). doi: 10.3791/50154. PMID: 24056408 Isolation and culture of neonatal mouse cardiomyocytes: Profile on PlumX Go to Pubmed, or ORCID for a complete list of publications.