Featured News

  • Saltman Quarterly Article


    Our work understanding and combating the development of Dilated Cardiomyopathy was featured in the Saltman Quarterly. More details and the article can be found here >


Featured Research Article

  • Overview figure of the 2025 Circulation Heart Failure manuscript: Combined Loss of Obsc and Obsl1 in Murine Hearts Results in Diastolic Dysfunction, Altered Metabolism, and Deregulated Mitophagy Check out our manuscript describing the cardiac phenotype of the obscurin/Obsl1 double knockout mouse is published in Circulation Heart Failure. Double knockouts develop diastolic dysfunction heart failure, marked by deregulated calcium handling, altered mitochondrial structure and metabolism, and deregulated autophagy/mitophagy.


  • Featured Review Article

    • 2025 Nat Rev Endocrin
      We recently contributed to a new review that summarises "The challenges of assessing adiposity in a clinical setting", available at Nature Reviews Endocrinology.


About the Lab

We investigate muscle development, signaling and maintenance, by studying the biological role of sarcomeric and muscle associated proteins. We are particularly interested to decipher molecular mechanisms that play a role in the development of cardiac and skeletal muscle myopathies.

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The lab is active at the Department of Biomedicine at Aarhus University and Steno Diabetes Center in Denmark, and the School of Medicine at UC San Diego in the US.

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Our laboratory is Green Lab Certified. We aim to do sustainable research to preserve the planets resources.

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News Feed

  • October 2025: Our highlight on "Novel links of ATG4 proteases to cytoskeletal adapters of the obscurin protein family" that summarizes work by Virginia Actis Dato & Kyohei Fujita is now available at Autophagy.

  • 2025 Autophagy Puncta article

  • September 2025: We presented data on the functions of Cullin-3 at the DANDRITE Community Meeting at Aarhus University

  • June 2025: We have something new 'cooking'. Our collaboration with Dr. Anthony Hessel and his team at Accelerated Muscle Biotechnologies saw 'first light' for some of our muscle samples at the Brookhaven National Laboratories National Synchrotron Light Source II beamline.
  • 2025 AMBiotech collaboration

  • May 2025: We presented data from our projects at the 2025 International Society for Heart Research Conference in Nara, Japan. Congratulations to Dr. Rob Johnson, who won a poster award at the meeting.
  • 2025 ISHR Meeting, Nara, Japan

Past news >

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