Featured News

  • Saltman Quarterly Article

    Our work understanding and combating the development of Dilated Cardiomyopathy was featured in the Saltman Quarterly. More details and the article can be found here >

Featured Research Article

  • Exploring obscurin and SPEG kinase biology This manuscript explores obscurin and SPEG kinase biology, thanks to our great team of collaborators, including Dr. Fleming at the University of Konstanz and the Borgeson lab at the University of Gothenburg. The open access article is published here.

  • Featured Review Article

    • The titin I-band as biomechanical and signaling hub
      Check out our review article on the titin N2B and N2A regions as biomechanical and metabolic signaling hubs in cross-striated muscles. The review was published in Biophysical Reviews.

About the Lab

We investigate muscle development, signaling and maintenance, by studying the biological role of sarcomeric and muscle associated proteins. We are particularly interested to decipher molecular mechanisms that play a role in the development of cardiac and skeletal muscle myopathies.

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The lab is active at the Department of Biomedicine at Aarhus University in Denmark and the School of Medicine at UC San Diego in the US.

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Our laboratory is Green Lab Certified. We aim to do sustainable research to preserve the planets resources.

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News Feed

  • October 2022: Very excited to share data on the Obscurin x Obsl1 double knockout mouse model at the 2022 EMBO metabolism workshop in Malaga! Great work by Dr. Fujita and our collaborators.
  • EMBO Workshop Malaga
  • October 2022: After 15+ years at at UC San Diego, I am excited to announce that the lab will transition to the Department of Biomedicine at Aarhus University. We will continue our quest to discover molecular mechanisms for sk.muscle and heart development, and for the aetiology of myopathies in both places, at UC San Diego and Aarhus University. Join the team in Aarhus: seeking postdocs & PhD students starting from 2023 onwards.
  • Aarhus university logo
  • September 2022: Kyohei presents the obscurin/Obsl1 double knockout model of diastolic heart failure at the 70th Annual Scientific Session of the Japanese College of Cardiology in Kyoto, Japan.
  • September 2022: Our preprint describing how ‘combined loss of obscurin and obscurin-like 1 in murine hearts results in diastolic dysfunction, altered metabolism and deregulated mitophagy’ is finally out at BioRxiv.
  • dKO BioRxiv preprint 2022

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