Stephan Lange - Research Laboratory

Featured News

  • Saltman Quarterly Article


    Our work understanding and combating the development of Dilated Cardiomyopathy was featured in the Saltman Quarterly. More details and the article can be found here >


Featured Research Article

  • Exploring obscurin and SPEG kinase biology This manuscript explores obscurin and SPEG kinase biology, thanks to our great team of collaborators, including Dr. Fleming at the University of Konstanz and the Borgeson lab at the University of Gothenburg. The open access article is published here.


    • Featured Review Article

    • 2024 Metabolism in HF Review
      Check out our review article on "Metabolic Flexibility of the Heart: The Role of Fatty Acid Metabolism in Health, Heart Failure, and Cardiometabolic Diseases". The review was published here.


About the Lab

We investigate muscle development, signaling and maintenance, by studying the biological role of sarcomeric and muscle associated proteins. We are particularly interested to decipher molecular mechanisms that play a role in the development of cardiac and skeletal muscle myopathies.

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The lab is active at the Department of Biomedicine at Aarhus University and Steno Diabetes Center in Denmark, and the School of Medicine at UC San Diego in the US.

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Our laboratory is Green Lab Certified. We aim to do sustainable research to preserve the planets resources.

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News Feed

  • March 2025: Our manuscript describing the cardiac phenotype of the obscurin/Obsl1 double knockout mouse is published in Circulation Heart Failure. Double knockouts develop diastolic dysfunction heart failure, marked by deregulated calcium handling, altered mitochondrial structure and metabolism, and deregulated autophagy/mitophagy.
    • Overview figure of the 2025 Circulation Heart Failure manuscript: Combined Loss of Obsc and Obsl1 in Murine Hearts Results in Diastolic Dysfunction, Altered Metabolism, and Deregulated Mitophagy

  • March 2025: We had a great visit to the lab of Prof. Katja Gehmlich @Birmingham University (UK) to learn about engineered heart tissues using iPSC-derived cardiomyocytes. A big thank you to the support by the Danish Cardiovascular Academy (DCA) who helped to make this happen.
    • 2025 Uni Birmingham visit

  • February 2025: Great to attend the 2025 Winter Meeting of the Danish Cardiovascular Academy and contribute with Christian Aalkjær & Emma Börgeson to the Grant writing Workshop. I hope all participants learnt something useful.
    • 2025 DCA Winter Meeting Norefjell Norway

Past news >

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